Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts
نویسندگان
چکیده
منابع مشابه
Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways.
OBJECTIVE Interleukin-18 (IL-18) is a proinflammatory cytokine implicated in the pathogenesis of rheumatoid arthritis (RA). This study was undertaken to examine the role of IL-18 in up-regulating secretion of the angiogenic factors stromal cell-derived factor 1alpha (SDF-1alpha)/CXCL12, monocyte chemoattractant protein 1 (MCP-1)/CCL2, and vascular endothelial growth factor (VEGF) in RA synovial...
متن کاملModulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts
INTRODUCTION Innate defence regulator (IDR) peptides are synthetic cationic peptides, variants of naturally occurring innate immune effector molecules known as host defence peptides. IDR peptides were recently demonstrated to limit infection-associated inflammation selectively without compromising host innate immune functions. This study examined the impact of a 12-amino acid IDR peptide, IDR-1...
متن کاملInterleukin-17 is a negative regulator of established allergic asthma
T helper (Th)17 cells producing interleukin (IL)-17 play a role in autoimmune and allergic inflammation. Here, we show that IL-23 induces IL-17 in the lung and IL-17 is required during antigen sensitization to develop allergic asthma, as shown in IL-17R-deficient mice. Since IL-17 expression increased further upon antigen challenge, we addressed its function in the effector phase. Most striking...
متن کاملInterleukin-1β switches electrophysiological states of synovial fibroblasts.
The role of electrophysiological events in signal transduction of interleukin-1β (IL-1β) was investigated in rabbit synovial fibroblasts using the perforated-patch method. Aggregated synovial fibroblasts occurred in two different electrophysiological states having membrane potentials ( V m) of -63 ± 4 ( n = 71) and -27 ± 10 mV ( n = 55) (high and low V m, respectively). IL-1β affected the cells...
متن کاملInterleukin-1b switches electrophysiological states of synovial fibroblasts
Kolomytkin, Oleg V., Andrew A. Marino, Kalia K. Sadasivan, Robert E. Wolf, and James A. Albright. Interleukin-1b switches electrophysiological states of synovial fibroblasts. Am. J. Physiol. 273 (Regulatory Integrative Comp. Physiol. 42): R1822–R1828, 1997.—The role of electrophysiological events in signal transduction of interleukin-1b (IL-1b) was investigated in rabbit synovial fibroblasts us...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2006
ISSN: 1063-4584
DOI: 10.1016/j.joca.2005.10.004